All articles by Derek Lowe – Page 5
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OpinionWhy modern chemists need to think big
The lessons we can learn from the larger reaction scales of the past
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OpinionFor the sake of argument
It’s important to recognise which disputes can actually be resolved by science
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BusinessTargeting rare diseases
Is working on genetic mutations that affect only a few in every thousand people risky?
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OpinionRise of the biologics
Antibodies, RNA and gene therapy don’t necessarily compete with small molecule drugs – and they all rely on chemistry
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OpinionAn opportunity ignored
Dismissing ideas that were ‘not invented here’ is like walking past a $100 bill
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OpinionMake room for randomness in drug development
Setting free the dark horses sometimes beats the most rational planning
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OpinionMaking enough of a difference
What if the needle in the drug development haystack ends up being too small to be useful?
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OpinionUnpicking a clinical trial death
A new study shows up off-target effects of a drug that proved deadly, and highlights the pitfalls of drug discovery
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OpinionHow safe should drugs be?
What does spotting new risks in approved medicines say about how effective regulators are?
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OpinionAlternate chemical realities
What would chemistry look like if key discoveries had happened differently?
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OpinionHow does being a chemist change your view on the world?
Scientific knowledge and analysis shape our view, but can also be selectively ignored
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OpinionOutlines of ignorance
There’s a lot about chemistry that we just don’t understand very well yet
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OpinionDrug regulation is a burden worth bearing
Calls to break down regulatory barriers show a misunderstanding of the industry
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OpinionHow much does fashion influence chemists?
Is that new reaction the next Nobel-worthy breakthrough, or just a flash in the pan?
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CareersThe trials and tribulations of drug discovery
The many pitfalls medicinal chemists face when creating a new drug
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OpinionPutting chemistry back in biology
The chemical nature of biomolecular interactions can no longer be ignored
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OpinionSlimmer synthesis
Atom economy is a noble aim, but there are other routes to efficient molecule making
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OpinionDon’t fear the Crispr
Does simple gene-editing mean the end of traditional medicinal chemistry? Probably not
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