Medicinal chemistry – Page 13
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ResearchTiny shear forces have big effect on protein reactions
Proteins react faster under the forces they experience when they squeeze through blood vessels
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NewsFirst malaria vaccine approved as hopes raised for new, better ones
Mosquirix prevents just 30% of severe malaria cases in young children prompting a guarded welcome
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ArticleAstraZeneca explores new frontiers through academic collaborations
The important of partnerships between industry and academia to drive innovation
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BusinessNew antiviral impresses against Covid-19
Merck & Co and Ridgeback’s molnupiravir reduces risk of hospitalisation and death, and may work against other coronaviruses
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OpinionWhere are the Covid-19 drugs?
Small molecules appear to be lagging behind development of vaccine and antibody treatments
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NewsIvermectin debacle exposes flaws in meta-analysis methodology
Health researchers warn that taking studies at face value is a luxury that they can no longer afford
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NewsChemistry Nobel predictions range from free-radical chemistry to MOFs
Data-crunching goes up against gut feeling as the chemistry community weighs in on their favourites for the world’s top chemistry prize
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ResearchProgrammable peptoid template for disrupting protein–protein interactions inside cells
System optimises residues involved in binding target independently from those that promote membrane permeability
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ResearchMethod to make unusual oligonucleotides could be a boon for gene therapy drugs
Synthesis can insert unusual linkages into DNA molecules while rivalling industry standard chemistry in speed and efficiency
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FeatureThe name’s bond, chemical bond
Kathryn Harkup explores the poisons – real and fictional – used in Bond films
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BusinessFully synthetic proteins make tailored medicines
Bright Peak Therapeutics makes modified protein drugs from scratch
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NewsExplainer: The science of alkyl nitrites aka poppers
From their origins as 19th century angina treatment to becoming an important part of gay subculture, these recreational drugs exist in a legal limbo
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BusinessThe future of ‘next generation’ DNA sequencing
As it gets cheaper and easier to read genetic code, its applications are expanding rapidly
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OpinionThe lifesaving work of Evelyn Hickmans
Anne Green tells us how a female chemist almost single-handedly established paediatric clinical chemistry and led to a first in global health
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NewsUS intelligence can’t agree if Covid-19 came from an animal or a lab
After months of investigation agencies remain divided on most likely origin of Sars-CoV-2
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BusinessUS grants Pfizer’s Covid-19 vaccine full approval
WHO calls for delay to booster programmes to allow more global distribution
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WebinarAutomated capsule chemistry with Synple: do more, faster
Synple’s automated synthesis technology allows discovery chemists to accelerate research and improve efficiency
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BusinessThe multi-pronged search for Covid-19 treatments
Drugs that block infection or reduce inflammation will complement vaccine protection
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BusinessBudget cuts at UK medicines regulator raise eyebrows
MHRA to cut 300 jobs amid financial pressures arising from Brexit
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NewsResearch and regulations face-up to a new era of non-animal testing alternatives
Hopes raised that approval for skin sensitisation test could mark the start of a raft of in vitro toxicity tests