Organic chemistry – Page 14
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ResearchApp creates floating 3D molecules from hand-drawn chemical structures
MolAR also lets users visualise molecules in water, coffee and fruit by scanning them with a smartphone camera
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ResearchGold(III) catalysis transforms protecting group from base-stable to base-labile
Unique orthogonality in a protecting group achieved using a gold-catalysed cyclisation for selective activation and deprotection
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ResearchMolecular cryo-EM discovers error in 25-year-old natural product structure
Nobel prize-winning biomolecule imaging technique adapted to characterise chemical compounds faster and easier than NMR and x-ray
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ResearchSafer fluorination process developed using flow electrochemistry
Automated system for constructing carbon–fluorine bonds quenches fluorine compounds to reduce exposure and risk to lab chemists
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ResearchTransient spectroscopy sheds light on elusive photoredox process
Study confirms mechanism of sensitisation-initiated electron transfer reaction following extended debate
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FeatureThe search for the grand unification of aromaticity
Researchers have been trying to find a full definition of aromaticity for almost two centuries, and yet keep discovering new types
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ResearchNewly discovered marine compound is in a super-carbon-chain league of its own
Isolated from algae, Benthol A has 35 stereocentres
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ResearchMolecular light switch speeds up tricky cyclodextrin synthesis
Reaction could lower cost of useful macrocycle
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ResearchChemists control reaction path with mechanical force
Mechanochemical mechanism exploited to access unconventional trajectories on a reaction’s potential energy surface
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ResearchChemists reconsider C–H and C–C bond length rationale
Quantitative proof for steric repulsion theory
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ResearchGlass catalysis screening study prompts reactionware rethink
Base-catalysed reactions are up to 1000 times faster in the presence of glass
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ResearchGold double helix assembles with DNA-like precision
DNA construction principles create first ever double-helical gold nanocluster assembly
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ResearchMolecular machines talk to living cells for the first time
Artificial molecular motors gently pull on cells’ membrane receptors to trigger a biochemical response
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ResearchOrigin of mysterious alpha effect in nucleophilic substitution reactions unveiled
Alpha nucleophiles’ ability to get close to electrophiles – rather than their intramolecular lone pair repulsion – gives them unusual reactivity
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ResearchFrom nerve agent simulant, to pharma ingredient
Portable microreactor offers a new way to dispose of paraoxon
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ResearchSortase A strategy could see ribosomal products reach further across chemical space
Compound libraries set to benefit from process that harnesses promiscuity of post-translation enzymes
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ResearchNanomaterial stores radicals to power photopolymerisation in the dark
Reaction driven by long-lived radicals experiences fewer side reactions than photopolymerisation under light irradiation