It's complicated
In a complex world, binary answers are often requested but rarely sufficient
If your work deals somehow with chemical substances and their effects on living creatures (medicinal chemistry, pharmacology, toxicology etc), the question you most dread is surely ‘Is this compound poisonous or not?’ To a layperson, this sounds like a completely reasonable thing to ask, a perfectly simple question that for some reason sends the degree-holders in lab coats into fits of explanation (‘it’s complicated…’), or sometimes just into fits.