Nickel catalyst switches on double stereochemistry in reaction between racemic alkanes

A scheme showing a doubly enantioconvergent substitution reaction

Source: © Science/AAAS

First-of-its-kind reaction creates stereocentres by stitching together racemic nucleophiles and electrophiles

Researchers have developed a reaction that has long been on many chemists’ wish list: joining up racemic alkanes to create a compound with two adjacent stereocentres in a single step. Experts describe this first-of-its-kind reaction as a powerful strategy for making particularly challenging carbon–carbon bonds.