Antigen-carrying adjuvants activate both adaptive and innate immunity
Aluminosilicate nanoparticles promote ion perturbation, pyroptosis and enhanced immunity in a cancer model
Researchers in China and Australia have developed an adjuvant system that activates both innate and adaptive immunity by inducing programmed cell death in dendritic cells. The system uses sodium-stabilised dendritic aluminosilicate nanoparticles, which can carry antigens and have basic sites that trigger pH-responsive H+–Na+ exchange. Compared to commercial and clinical adjuvants in an in vivo colon cancer model, the nanoparticles triggered a stronger immune response.