D-trypsin synthesis enables sequencing of mirror-image proteins

D-proteins

Source: © Guanwei Zhang and Ting F Zhu/Springer Nature Limited 2024

Reversing the chirality of a protein-digesting enzyme could aid the development of mirror-image therapeutics

By synthesising a mirror-image version of protein-digesting enzyme trypsin, scientists in China have pioneered a method of sequencing D-proteins. The strategy could aid the development of promising mirror-image peptide and protein therapeutics.