Sodium lumps, glucose and mechanochemistry behind ammonia-free Birch reduction

Structures

Source: © Hajime Ito/Hokkaido University

Protocol solves ‘malleability problem’ of activating alkali metals like sodium

Researchers in Japan have designed a mechanochemical protocol for the Birch reduction that works in air, at room temperature. It uses glucose to disperse sodium lumps into small, reactive particles, which promote the reaction, whilst avoiding the use of liquid ammonia.