PFAS-free synthesis of fluorinated drugs and pesticides
By 
Rebecca Trager2024-09-16T08:30:00
Flow chemistry introduces trifluoromethyl group onto a range of compounds using just caesium fluoride as the fluorine source
Chemists at the University of Amsterdam have developed a method that avoids the use of per- and polyfluoroalkyl substances (PFAS) in the synthesis of fluorinated compounds. Their approach offers a more environmentally-friendly route to compounds with a trifluoromethyl group attached at a sulfur, nitrogen or oxygen, which provides unique features for drug molecules and agrochemicals.